Circulating Coronary Blood Volume.

• The development of catheterization and indicator dilution techniques has made it possible to measure the volume of circulating blood within many organs in the intact animal. Hirche and Lochner injected measured amounts of dye into the coronary arteries of dogs and recorded the subsequent time course of dye concentration in blood from the coronary sinus. From this single curve both coronary blood flow and mean coronary circulation time were obtained, and the corresponding volume of circulating coronary blood was calculated. In the present studies circulating coronary blood volume (CCBV) was measured in dogs by a somewhat different approach, using independent isotope and dye injection methods to measure the rate of coronary blood flow and the coronary circulation time.